Dr. Brad Wouters Publications

  1. Lumba, MA, Willis, LM, Santra, S, Rana, R, Schito, L, Rey, S, Wouters, BG, Nitz, M (2017). A β-galactosidase probe for the detection of cellular senescence by mass cytometry. Org. Biomol. Chem.15,6388-6392.
  2. Rey, S, Schito, L, Wouters, BG, Eliasof, S, Kerbel, RS (2017). Targeting Hypoxia-Inducible Factors for Antiangiogenic Cancer Therapy. Trends Cancer3,529-541.
  3. Leung, E, Cairns, RA, Chaudary, N, Vellanki, RN, Kalliomaki, T, Moriyama, EH, Mujcic, H, Wilson, BC, Wouters, BG, Hill, R et al. (2017). Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors. BMC Cancer17,418.
  4. Tan, Q, Joshua, AM, Wang, M, Bristow, RG, Wouters, BG, Allen, CJ, Tannock, IF (2017). Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity. Cancer Chemother. Pharmacol.79,959-969.
  5. Chowdhury, S, Yung, E, Pintilie, M, Muaddi, H, Chaib, S, Yeung, M, Fusciello, M, Sykes, J, Pitcher, B, Hagenkort, A et al. (2016). MATE2 Expression Is Associated with Cancer Cell Response to Metformin. PLoS ONE11,e0165214.
  6. Adriaens, ME, Prickaerts, P, Chan-Seng-Yue, M, van den Beucken, T, Dahlmans, VEH, Eijssen, LM, Beck, T, Wouters, BG, Voncken, JW, Evelo, CTA et al. (2016). Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia. Epigenetics Chromatin9,48.
  7. Maeda, A, Chen, Y, Bu, J, Mujcic, H, Wouters, BG, DaCosta, RS (2017). In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model. Int. J. Radiat. Oncol. Biol. Phys.97,184-194.
  8. Prickaerts, P, Adriaens, ME, Beucken, TVD, Koch, E, Dubois, L, Dahlmans, VEH, Gits, C, Evelo, CTA, Chan-Seng-Yue, M, Wouters, BG et al. (2016). Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3. Epigenetics Chromatin9,46.
  9. Rey, S, Schito, L, Koritzinsky, M, Wouters, BG (2017). Molecular targeting of hypoxia in radiotherapy. Adv. Drug Deliv. Rev.109,45-62.
  10. Taylor, E, Yeung, I, Keller, H, Wouters, BG, Milosevic, M, Hedley, DW, Jaffray, DA (2016). Quantifying hypoxia in human cancers using static PET imaging. Phys Med Biol61,7957-7974.
  11. Connor, AA, Denroche, RE, Jang, GH, Timms, L, Kalimuthu, SN, Selander, I, McPherson, T, Wilson, GW, Chan-Seng-Yue, MA, Borozan, I et al. (2017). Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma. JAMA Oncol3,774-783.
  12. Rodenhizer, D, Cojocari, D, Wouters, BG, McGuigan, AP (2016). Development of TRACER: tissue roll for analysis of cellular environment and response. Biofabrication8,045008.
  13. Edgar, LJ, Vellanki, RN, McKee, TD, Hedley, D, Wouters, BG, Nitz, M (2016). Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution. Angew. Chem. Int. Ed. Engl.55,13159-13163.
  14. Banh, RS, Iorio, C, Marcotte, R, Xu, Y, Cojocari, D, Rahman, AA, Pawling, J, Zhang, W, Sinha, A, Rose, CM et al. (2016). PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat. Cell Biol.18,803-813.
  15. Molavian, HR, Goldman, A, Phipps, CJ, Kohandel, M, Wouters, BG, Sengupta, S, Sivaloganathan, S (2016). Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects. Sci Rep6,27439.
  16. Hunter, FW, Wouters, BG, Wilson, WR (2016). Hypoxia-activated prodrugs: paths forward in the era of personalised medicine. Br. J. Cancer114,1071-7.
  17. Rodenhizer, D, Gaude, E, Cojocari, D, Mahadevan, R, Frezza, C, Wouters, BG, McGuigan, AP (2016). Erratum: A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients. Nat Mater15,244.
  18. Rodenhizer, D, Gaude, E, Cojocari, D, Mahadevan, R, Frezza, C, Wouters, BG, McGuigan, AP (2016). A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients. Nat Mater15,227-34.
  19. Hill, RP, Bristow, RG, Fyles, A, Koritzinsky, M, Milosevic, M, Wouters, BG (2015). Hypoxia and Predicting Radiation Response. Semin Radiat Oncol25,260-72.
  20. Hunter, FW, Young, RJ, Shalev, Z, Vellanki, RN, Wang, J, Gu, Y, Joshi, N, Sreebhavan, S, Weinreb, I, Goldstein, DP et al. (2015). Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs. Cancer Res.75,4211-23.
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