REVIEW: Targeting tumour hypoxia to prevent cancer metastasis.
J Enzyme Inhib Med Chem. 2014 Oct 27:1-33. Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology […]
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Congratulations to Ronald Wu on being awarded the 2014-2015 EIRR21 Award!
Ronald will be part of the Excellence in Radiation Research for the 21st century (EIRR21st) Research Training Program funded by CIHR
RNF8-Independent Lys63 Poly-Ubiquitylation Prevents Genomic Instability in Response to Replication-Associated DNA Damage.
Ramaekers CH, van den Beucken T, Bristow RG, Chiu RK, Durocher D, Wouters BG. PLoS One. 2014 Feb 28;9(2):e89997. doi: 10.1371/journal.pone.0089997. eCollection 2014. Abstract The cellular
Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response.
Clin Cancer Res. 2013 Dec 15;19(24):6741-50. doi: 10.1158/1078-0432.CCR-13-1787. Epub 2013 Oct 18. Zannella VE1, Dal Pra A, Muaddi H, McKee TD, Stapleton S, Sykes J, Glicksman R, Chaib
“Two phases of disulfide bond formation have differing requirements for oxygen” J Cell Biology
Koritzinsky M, Levitin F, van den Beucken T, Rumantir RA, Harding NJ, Chu KC, Boutros PC, Braakman I, Wouters BG. J Cell Biol. 2013 Nov 18. Full text. Abstract Most
Hypoxic Activation of the PERK/eIF2α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3
Hypoxic Activation of the PERK/eIF2α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3 Mujcic H, Nagelkerke A, Rouschop
Contributions of AMPK and p53 dependent signaling to radiation response in the presence of metformin.
Contributions of AMPK and p53 dependent signaling to radiation response in the presence of metformin. Muaddi H, Chowdhury S, Vellanki R, Zamiara P, Koritzinsky M.
The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia
The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia. Schaaf MB, Cojocari Dan , Keulers TG, Jutten B, Starmans MH, de Jong MC, Begg