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Support our PMH Hypoxia Program Team for TERRY FOX RUN 2012 !

The WK Lab has raised funds and participated in the Terry Fox Run at Wilket Creek Park for the past two years. This year we are proudly supporting The Terry Fox Foundation in its ongoing work to fund innovative and progressive cancer research programs. Please support our team by joining, or making a donation. Your kindness will ... Read More

WK Lab welcomes our new staff Sanjana Chowdhury, Mahbuba Meem and Hala Muaddi!

Mahbuba Meem joined our lab as our new laboratory technician. Sanjana Chowdhury is a new Masters candidate at the Institute of Medical Sciences (IMS) at University of Toronto under the supervision of Dr. Marianne Koritzinsky. Hala Muaddi is a second year medical student that will engage in part-time research under the supervision of Dr. Marianne Koritzinsky as part of the Comprehensive ... Read More

Dr. Marianne Koritzinsky receives Terry Fox New Investigator Award

Congratulations to Dr. Koritzinsky! The highly competitive grant was awarded to Dr. Koritzinsky for her work entitled “the impact of hypoxia on the maturation of extracellular proteins that regulate tumour metabolism.   About the award The purpose of the award to provide outstanding young researchers with support as they develop their career as independent research scientists ... Read More

Dr. Brad Wouters Recognized for his Contributions to Radiotherapy

Dr. Bradly Wouters, Senior Scientist and Director of the Hypoxia and Microenvironment Program at OCI, was awarded the Klaas Breur Gold Medal Award from the European Society for Therapeutic Radiotherapy and Oncology (ESTRO). The Klaas Breur Award was given in recognition of Dr. Wouters major scientific contributions to the field of radiotherapy and is the ... Read More

Translational control is a major contributor to hypoxia induced gene expression

Twan van den Beucken, Michael G. Magagnin, Barry Jutten, Renaud Seigneuric, Philippe Lambin, Marianne Koritzinsky and Bradly G. Wouters ,  28 June 2011  Abstract Background and purpose Hypoxia is a common feature of solid tumors that is associated with an aggressive phenotype, resistance to therapy and poor prognosis. Major contributors to these adverse effects are the transcriptional program activated by the HIF family of transcription factors as well as the translational response mediated ... Read More

AMPK regulates metabolism and survival in response to ionizing radiation

Vanessa E. Zannella, Dan Cojocari, Susan Hilgendorf, Ravi N. Vellanki, Stephen Chung, Bradly G. Wouters and Marianne Koritzinsky Volume 99, Issue 3 , Pages 293-299, June 2011   Abstract Background and purpose AMPK is a metabolic sensor and an upstream inhibitor of mTOR activity. AMPK is phosphorylated by ionizing radiation (IR) in an ATM dependent manner, but the cellular consequences of this phosphorylation event ... Read More