Contributions of AMPK and p53 dependent signaling to radiation response in the presence of metformin. Muaddi H, Chowdhury S, Vellanki R, Zamiara P, Koritzinsky M. Radiother Oncol. 2013 Jul 25. pii: S0167-8140(13)00292-2. doi: 10.1016/j.radonc.2013.06.014. [Epub ahead of print] Source Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Faculty of Medicine, ... Read More
The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia. Schaaf MB, Cojocari Dan , Keulers TG, Jutten B, Starmans MH, de Jong MC, Begg AC, Savelkouls KG, Bussink J, Vooijs M, Wouters BG, Rouschop KM. Radiother Oncol. 2013 Jul 9. pii: S0167-8140(13)00293-4. doi: 10.1016/j.radonc.2013.06.015. [Epub ahead of print]Department of Radiation Oncology (Maastro Lab), GROW School for Oncology & Developmental Biology, Maastricht University Medical Center+, Maastricht, ... Read More
New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1α signaling is essential for promoting adaptation and survival to hypoxia. Cojocari Dan, Vellanki R.N., Sit B., Uehling D., Koritzinsky M., Wouters B.G.. Abstract BACKGROUND AND PURPOSE: The unfolded protein response (UPR) is activated in response to hypoxia-induced stress in the endoplasmic reticulum (ER) and consists of three ... Read More
PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS Kasper M. Rouschop, Ludwig J. Dubois, Tom G. Keulers, Twan van den Beucken, Philippe Lambin, Johan Bussink, Albert J. van der Kogel, Marianne Koritzinsky, and Bradly G. Wouters Abstract Hypoxia is a common feature of tumors and an important ... Read More
The WK Lab has raised funds and participated in the Terry Fox Run at Wilket Creek Park for the past two years. This year we are proudly supporting The Terry Fox Foundation in its ongoing work to fund innovative and progressive cancer research programs. Please support our team by joining, or making a donation. Your kindness will ... Read More
MBP Excellence OSOTF scholarship is funded by an endowment created by Ontario Cancer Institute/Princess Margaret Hospital, the Province of Ontario and the University of Toronto. The awards are in addition to more than $1.4 million won in external competitive scholarships by Medical Biophysics students this year.
Mahbuba Meem joined our lab as our new laboratory technician. Sanjana Chowdhury is a new Masters candidate at the Institute of Medical Sciences (IMS) at University of Toronto under the supervision of Dr. Marianne Koritzinsky. Hala Muaddi is a second year medical student that will engage in part-time research under the supervision of Dr. Marianne Koritzinsky as part of the Comprehensive ... Read More
Dr Marianne Koritzinsky will oversee the operation of the Terry Fox Foundation Strategic Initiative for Excellence in Radiation Research for the 21st Century at CIHR (EIRR21) Training Program as the new program co-Director.