Congratulations to Dr. Koritzinsky! The highly competitive grant was awarded to Dr. Koritzinsky for her work entitled “the impact of hypoxia on the maturation of extracellular proteins that regulate tumour metabolism. About the award The purpose of the award to provide outstanding young researchers with support as they develop their career as independent research scientists ... Read More
Dr. Bradly Wouters, Senior Scientist and Director of the Hypoxia and Microenvironment Program at OCI, was awarded the Klaas Breur Gold Medal Award from the European Society for Therapeutic Radiotherapy and Oncology (ESTRO). The Klaas Breur Award was given in recognition of Dr. Wouters major scientific contributions to the field of radiotherapy and is the ... Read More
Twan van den Beucken, Michael G. Magagnin, Barry Jutten, Renaud Seigneuric, Philippe Lambin, Marianne Koritzinsky and Bradly G. Wouters , 28 June 2011 Abstract Background and purpose Hypoxia is a common feature of solid tumors that is associated with an aggressive phenotype, resistance to therapy and poor prognosis. Major contributors to these adverse effects are the transcriptional program activated by the HIF family of transcription factors as well as the translational response mediated ... Read More
Vanessa E. Zannella, Dan Cojocari, Susan Hilgendorf, Ravi N. Vellanki, Stephen Chung, Bradly G. Wouters and Marianne Koritzinsky Volume 99, Issue 3 , Pages 293-299, June 2011 Abstract Background and purpose AMPK is a metabolic sensor and an upstream inhibitor of mTOR activity. AMPK is phosphorylated by ionizing radiation (IR) in an ATM dependent manner, but the cellular consequences of this phosphorylation event ... Read More
Chantal H.M.A. Ramaekers, Twan van den Beucken, Alice Meng, Shaqil Kassam, John Thoms, Robert G. Bristow, Bradly G. Wouters 04 July 2011 Background and purpose Hypoxia is a common feature of the microenvironment of solid tumors which has been shown to promote malignancy and poor patient outcome through multiple mechanisms. The association of hypoxia with ... Read More
Kasper M. A. Rouschop, Ludwig Dubois, Marco B. E. Schaaf, Twan van den Beucken, Natasja Lieuwes, Tom G. H. Keulers, Kim G. M. Savelkouls, Johan Bussink, Albert J. van der Kogel, Marianne Koritzinsky, Bradly G. Wouters Background and purpose: Tumour hypoxia is an important limiting factor in the successful treatment of cancer. Adaptation to hypoxia includes inhibition of mTOR, causing scavenging of eukaryotic initiation factor 4E (eIF4E), the rate-limiting ... Read More
Kasper M.A. Rouschop, Twan van den Beucken, Ludwig Dubois, Hanneke Niessen, Johan Bussink, Kim Savelkouls, Tom Keulers, Hilda Mujcic, Willy Landuyt, Jan Willem Voncken, Philippe Lambin, Albert J. van der Kogel, Marianne Koritzinsky, Bradly G. Wouters Published in Volume 120, Issue 1 J Clin Invest. 2010;120(1):127–141 Tumor hypoxia is a common microenvironmental factor that adversely ... Read More
Bradly G. Wouters & Marianne Koritzinsky Abstract Hypoxia occurs in the majority of tumours, promoting angiogenesis, metastasis and resistance to therapy. Responses to hypoxia are orchestrated in part through activation of the hypoxia-inducible factor family of transcription factors (HIFs). Recently, two additional O2-sensitive signalling pathways have also been implicated: signalling through the mammalian target of rapamycin ... Read More